Radiesse® is considered a dermal filler that combines science and aesthetics. Once a site is injected, it provides immediate contouring by filling wrinkles and folds. The calcium hydroxylapatite (CaHA) microspheres gel matrix is effective for moderate to severe facial wrinkles and folds, including nasolabial folds (smile lines), marionette lines, downturned corners of the mouth, and pre-jowl folds (sagging skin on either side of the chin). It brings back volume to the hands, particularly for areas affected by HIV-associated fat loss, also known as lipoatrophy. Also it is excellent for providing volume and contour to the cheeks.